Figure 3: Effect of topical administration of the ethanol extract of Nasturtium officinale on chronic inflammation induced by TPA in mice (2.5 μg/ear × 5 times). The extract (5 mg/ear), dexamethasone (0.5 mg/ear), and acetone were administrated immediately after TPA application and 6 h later for 9 days. The values represent the mean variation in the ear weight ± S.E.M (n = 6). ***P < 0.001 indicates significant differences compared to the TPA group. TPA, 12-O-tetradecanoyl phorbol 13-acetate.