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  Indian J Med Microbiol
 

Figure 1: Microscopic presentation of the colon in acetic acid-induced colitis in rats (hematoxylin and eosin staining). (A) Normal group: normal mucus layer and crypts; (B) acetic acid control group: destruction of epithelium, architectural deformity of the crypts and infiltration of inflammatory cells; (C) dexamethasone (1 mg/kg): mild to moderate inflammation of mucosa and submucosa and mucosal inflammatory cell infiltrates; (D-F) pregabalin (30, 50, and 100 mg/kg, respectively): epithelial regeneration and reduction in the number of inflammatory cells in lamina propria.

Figure 1: Microscopic presentation of the colon in acetic acid-induced colitis in rats (hematoxylin and eosin staining). (A) Normal group: normal mucus layer and crypts; (B) acetic acid control group: destruction of epithelium, architectural deformity of the crypts and infiltration of inflammatory cells; (C) dexamethasone (1 mg/kg): mild to moderate inflammation of mucosa and submucosa and mucosal inflammatory cell infiltrates; (D-F) pregabalin (30, 50, and 100 mg/kg, respectively): epithelial regeneration and reduction in the number of inflammatory cells in lamina propria.