Figure 7: Effect of oxypeucedanin and isoimperatorinon on D OX-induced reactive oxygen species overproduction. Cells pretreated with oxypeucedanin and isoimperatorin (80 μg/mL) 2 h and 21 h, respectively, before exposure to DOX 5 μM. Data are represented as mean ± SEM for three independent experiments. ***P < 0.001 Indicates signific ant difference in comparison to the control group, ##P < 0.01 and ###P < 0.001 versus DOX-treated cells. DOX, Doxorubicin; ISO, isoimperatorin; OXY, oxypeucedanin.