Research in Pharmaceutical Sciences

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 12  |  Issue : 2  |  Page : 99--106

Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model


Hidayat Sulistyo1, Dhadhang Wahyu Kurniawan2, Lantip Rujito3 
1 Department of Pathological Anatomy, Faculty of Medicine, Jenderal Soedirman University, Indonesia
2 Department of Pharmaceutices, Faculty of Health Sciences, Jenderal Soedirman University, Indonesia
3 Department of Molecular Biology, Faculty of Medicine, Jenderal Soedirman University, Indonesia

Correspondence Address:
Lantip Rujito
Department of Molecular Biology, Faculty of Medicine, Jenderal Soedirman University
Indonesia

Transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. Since there are many obstacles in the use of deferoxamin (DFO) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. The study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of DFO and nanoparticles of green tea extract. The research used experimental research design with a post-test only control group. Experimental nano green teas were divided into four treatment groups; no diet, DFO supplementation, nano green tea supplementation, and a combination of both DFO and green tea. Ferritin and glutathione peroxides were used as biochemical parameters, and histopathological pictures of the heart and spleen were recorded. The study showed that there was significant improvement in the rats receiving DFO and nanoparticles of green tea compared with the rats in the no diet group. The study also reported that nano green tea has an effect comparable to DFO.


How to cite this article:
Sulistyo H, Kurniawan DW, Rujito L. Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model.Res Pharma Sci 2017;12:99-106


How to cite this URL:
Sulistyo H, Kurniawan DW, Rujito L. Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model. Res Pharma Sci [serial online] 2017 [cited 2023 Jan 30 ];12:99-106
Available from: https://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=2;spage=99;epage=106;aulast=Sulistyo;type=0