Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale

Mostafa Mostafazadeh; Heibatollah Sadeghi; Hossein Sadeghi; Vahid Zarezade; Abolghasem Hadinia; Esmaeel Panahi Kokhdan

doi:10.4103/1735-5362.343084

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ORIGINAL ARTICLE

Year : 2022 | Volume : 17 | Issue : 3 | Page : 305-314

Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale

Mostafa Mostafazadeh¹, Heibatollah Sadeghi², Hossein Sadeghi³, Vahid Zarezade⁴, Abolghasem Hadinia⁵, Esmaeel Panahi Kokhdan⁶
¹ Department of Biochemistry and Clinical Laboratories; Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, I.R. Iran
² Medicinal Plants Research Center; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran
³ Medicinal Plants Research Center; Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, I.R. Iran
⁴ Department of Clinical Biochemistry, Faculty of Medicine, Behbahan University of Medical Sciences, Behbahan, I.R. Iran
⁵ Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran
⁶ Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran

Correspondence Address:
Hossein Sadeghi
Medicinal Plants Research Center; Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj
I.R. Iran

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/1735-5362.343084

Background and purpose: Previously, we reported the anti-inflammatory properties of Nasturtium officinale (watercress) in several models of acute inflammation. This study was designed to explore the effects of topical and systemic administrations of N. officinale in the two chronic inflammatory models and to evaluate the role of TNF-α and IL-1β in these effects. Experimental approach: Folin-Ciocalteu and aluminum chloride methods were used to estimate the extract’s total phenol and flavonoid content, respectively. Carrageenan-induced paw edema was carried out and TNF-α and IL-1β concentrations in the carrageenan-treated paw tissue were determined. Formalin injection into rat hind paws (7 days) and the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on mouse ears (9 days) were used to simulate chronic inflammation. Furthermore, a histological assessment of the inflamed tissues was carried out. Findings/Results: The extract’s flavonoid and phenolic contents were 90.26 ± 4.81 mg rutin equivalents/g and 68 ± 8.16 gallic acid equivalents/g gallic acid, respectively. N. officinale pretreatment in all doses administered considerably decreased carrageenan-induced edema. The extract also reduced IL-1β levels in carrageenan- treated paws while did not affect TNF-α levels. Oral and topical administrations of N. officinale considerably reserved the paw and ear edema. The extract also ameliorated the tissue injuries due to formalin and TPA challenges. Conclusion and implications: The data confirmed the topical and systemic anti-inflammatory effects of watercress against two chronic models of inflammation. They suggested that these properties are not related to TNF-α but could be attributed to inhibition of IL-1β and inhibition of leukocyte infiltration.

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Anti-inflammatory; Interleukin-1 beta; Nasturtium officinale; Tetradecanoyl phorbol acetate; Tumor necrosis factor-alpha

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