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ORIGINAL ARTICLE
Year : 2022  |  Volume : 17  |  Issue : 1  |  Page : 35-42

Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats


1 Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, I.R. Iran; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands
2 Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, I.R. Iran
3 Department of Pathology and Histology, School of Medicine, Guilan University of Medical Sciences, Rasht, I.R. Iran
4 Department of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, I.R. Iran

Correspondence Address:
Azadeh Motavallian
Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam

Ehsan Zamani
Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht
I.R. Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-5362.329924

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Background and purpose: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease characterized by the inflammation of the intestine. The available medicinal treatments for IBD are not efficacious enough since they exert various adverse effects. Therefore, the search for new therapeutic agents should be continued. The present study aimed to assess the anti-inflammatory effects of pregabalin on acetic acid-induced colitis in rats. Experimental approach: Using 2 mL of 3% acetic acid solution, colitis was intra-rectally induced in rats. Animals were randomly divided into 6 groups including the normal group, colitis control group, pregabalin treatment groups (30, 50, and 100 mg/kg; i.p., respectively), and dexamethasone treatment group (1 mg/kg; i.p.). Macroscopic, microscopic, and biochemical (myeloperoxidase, tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta) examinations were used to evaluate the efficacy of pregabalin in the inflamed colon. Findings/Results: All the applied doses of pregabalin significantly decreased the severity of macroscopic and microscopic colonic damages including ulcer severity, ulcer area, percentage of necrosis, and total colitis index compared to the colitis control group. These results were confirmed by the reduced colonic concentration of tumor necrosis factor-alpha, interleukin-6, interleukin-1 beta, and myeloperoxidase activity. Conclusion and implications: Results of this study indicated that pregabalin administration has beneficial effects upon the treatment of experimental colitis, which might be partly due to its anti-inflammatory properties.


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