Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 683
  • Home
  • Print this page
  • Email this page

 Table of Contents  
Year : 2018  |  Volume : 13  |  Issue : 4  |  Page : 288-303

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

1 Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
2 Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran

Date of Web Publication2-Jul-2018

Correspondence Address:
Soliman Mohammadi-Samani
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz
I.R. Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1735-5362.235156

Rights and Permissions

During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.

Keywords: Drug delivery systems; Nanoparticles; Nanostructured lipid carriers (NLCs); Routes of administration; Solid lipid nanoparticles (SLNs)

How to cite this article:
Ghasemiyeh P, Mohammadi-Samani S. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharma Sci 2018;13:288-303

How to cite this URL:
Ghasemiyeh P, Mohammadi-Samani S. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharma Sci [serial online] 2018 [cited 2021 Dec 6];13:288-303. Available from: https://www.rpsjournal.net/text.asp?2018/13/4/288/235156

  1. Introduction Top

Lipid nanoparticles as drug delivery systems were considered from the beginning of the 19th century by professor R. H. Müller from Germany and Professor M. Gascon from Italy [1],[2]. These nanoparticles are manufactured from solid or mixture of solid and liquid lipids and stabilized by emulsifiers.

Lipids used in these nanoparticles are biocompatible and completely tolerated by the body like triglycerides, fatty acids, steroids, and waxes. In addition, using combination of emulsifiers could stabilize the formulations more efficiently. Lipid nanoparticles have many advantages in comparison to other particulate systems such as the ease of large-scale production [3], biocompatible and biodegradable nature of the materials [4], low toxicity potential [5], possibility of controlled and modified drug release [6], drug solubility enhancement and the possibility of both hydrophilic and lipophilic drug incorporation. Lipid nanoparticles are different from micro-emulsions, which are clear thermodynamically stable dispersion of oil and water that are stabilized by surfactants and cosurfactants [7],[8]. The most important parameters in lipid nanoparticles characterization are particle size and size distribution, zeta potential, polymorphism, degree of crystallinity, drug loading, entrapment efficiency, and drug release. There are three different types of lipid nanoparticles: homogenous drug-lipid matrix, drug enriched core and drug enriched shell. Drug release from lipid nanoparticles is mostly dependent on the matrix type and location of drug in matrix formulation; for example in the third type, drug release from the nanocarriers shows more sustained release profile. The composition of lipid matrix, surfactant concentration and manufacturing parameters, such as temperature and stirring rate, can also affect drug release profiles. Probably the most important reasons of using lipid nanoparticles, as a suitable alternative of previous polymeric nanoparticles, are the ease of large-scale production and their low toxicity potential [1].

  2. Types of Lipid Nanoparticles Top

Solid lipid nanoparticles (SLNs) are the first generation of lipid-based nanocarriers that are formulated from lipids, which are solid in the body temperature and stabilized by emulsifiers [1]. SLNs have submicron (less than 1000 nm) sizes [9]. They have numerous advantages such as drug protection against harsh environmental situations, ease of large scale production using high pressure homogenization technique, biocompatibility, and biodegradability [10]. SLNs have also some disadvantages; because of their perfect crystalline structure, they have low drug loading efficiency [10] and the possibility of drug expulsion due to the crystallization process during the storage conditions. Another drawback is initial burst release [11] which usually occurs with these formulations. In SLNs drug molecules orients between the fatty acid chains or glycerides and during the storage periods and polymorphic changes in solid lipid structures there is a tendency to expulsion of previously dissolved drug in SLNs. [Figure 1] illustrates the actual place of drug orientation in SLNs and nanostructured lipid carriers (NLCs) schematically.
Figure 1: Schematic view of the solid lipid nanoparticle (SLN) and nanostructured lipid carriers (NLCs) showing the drug location within the lipid matrix.

Click here to view

NLCs are second generation of lipid-based nanocarriers formed from mixture of solid and liquid lipids and have unstructured-matrix due to the different moieties of the constituents of NLCs [2]. NLCs were designed in order to overcome the SLNs limitations. NLCs have higher drug loading capacity because of imperfect crystal structure and could avoid drug expulsion by avoiding lipid crystallization during the manufacturing and storage periods. Due to the presence of liquid lipids in NLCs formulation expulsion of loaded drug after formulation and during the storage period is minimized. NLCs also can increase drug solubility in lipid matrix and they can show more controllable release profiles in comparison to SLNs [12]. Although NLCs are solid in nature even in body temperature but they have low melting point than SLNs and due to their unstructured nature and imperfection in their crystalline behaviors provide more space for drug dissolution and payload in liquid part of the NLCs. In this regard, loading capacity in NLCs are more than SLNs. Previous researches also confirm on less susceptibility of NLCs than SLNs to gelation during the preparation and storage period, which is another advantage of NLCs, NLCs can facilitate separation of nanoparticle from the rest of the medium and dosage form preparation for parenteral administration [2],[12].

  3. Methods of Lipid Nano-Particles Preparation Top

Lipid nanoparticles could be prepared by different methods such as hot and cold high pressure homogenization [13],[14], solvent emulsification/evaporation [15], microemulsion formation technique [16], and ultrasonic solvent emulsification [3]. Large-scale productions of lipid nanoparticles are mainly obtained by high pressure homogenization technique.

3.1. High pressure homogenization technique

3.1.1. Hot high pressure homogenization

In this method, lipid phase is heated up to 90 °C, then the hot lipid phase is dispersed in aqueous phase containing surfactants with same temperature. The pre-emulsion is homogenized at 90 °C under 3 cycles of high pressure homogenizer at 5 × 107 Pa. Finally, the obtained oil in water emulsion is cooled down to room temperature to solidify SLNs or NLCs [17].

3.1.2. Cold high pressure homogenization

In this method, the melted lipid phase is cooled to solidify and then ground to form lipid microparticles. Obtained lipid microparticles are dispersed in cool aqueous phase containing surfactants to form pre-suspension. Then the pre-suspension is homogenized under 5 cycles of high pressure homogenizer at room temperature and pressure of 1.5 × 108 Pa [18].

3.2. Solvent emulsification/evaporation technique

In this method, lipid phase is dissolved in an organic solvent such as acetone (organic phase). Then the organic phase is added to the aqueous phase (surfactant solution in water) under continuous stirring at 70-80 °C. The stirring will be continued until the organic phase is completely evaporated. Then obtained nanoemulsion is cooled (below 5 °C) to solidify lipid nanoparticles [15].

3.3. Microemulsion formation technique

In this method, lipids are melted at appropriate temperature and aqueous phase containing surfactants are heated up to same temperature. Then the hot aqueous phase will be added to the melted lipids under stirring at the same temperature. The hot oil in water microemulsion is dispersed in cold water at 1:50 ratio to solidify lipid nanoparticles [19].

3.4. Ultrasonic solvent emulsification technique

In this method, lipid phase is dissolved in an organic solvent such as dichloromethane and heated up to 50 °C. Then, aqueous phase containing surfactants and emulsifiers is heated up to the same temperature. After partial evaporation of dichloromethane, the aqueous phase is added to the organic phase under stirring at 50 °C. Obtained emulsion is sonicated for appropriate time and finally cooled in an ice bath to solidify lipid nanoparticles [3].

  4. Lipid Nanoparticles Applications and Different Routes of Administration Top

Numerous articles are reviewed and the results are categorized according to the routes of drug administration to six topics of topical, oral, parenteral, ocular, lung and brain delivery as shown in [Table 1].
Table 1: Different loaded active compound and routes of administration of lipid nanoparticles.

Click here to view

4.1. Topical route of administration

Skin related diseases are very common around the world. The major limitations for treatment of these diseases are low drug efficacy because of poor skin penetration or skin permeation of drugs from the most conventional formulations. Stratum corneum of epidermis is the major skin barrier and it should be bypassed through changing the penetration pathway from transcellular to paracellular or follicles. Lipid nanoparticles such as SLNs and NLCs have been developed to increase skin penetration or permeation. These particulate formulations are manufactured by mixing SLNs or NLCs with conventional formulations. They could be directly prepared in a one-step process which produce drug-loaded SLNs or NLCs. Lipid nanoparticles have so many advantages for topical drug delivery such as biocompatibility and biodegradability, controlled and extended drug release profile, close contact and strong skin adhesion, skin hydration and film formation in order to increase skin and dermal penetration [Table 2] [27],[29],[35],[36],[40].
Table 2: Lipid nanoparticles advantages and disadvantages as topical drug delivery systems.

Click here to view

4.2. Oral route

Oral drug administration is the most common route of drug delivery system because of the highest patient compliance. Low oral bioavailability due to limited drug solubility and/or high hepatic first pass effect are the most important limitations in oral drug delivery that should be overcome. Nanoparticle-based drug delivery systems were considered as suitable delivery system to increase oral bioavailability. Lipid nanoparticles such as SLNs and NLCs have the advantage of sustained drug release capability to maintain a constant plasma levels. In addition, nanoparticles with higher specific surface area and higher saturation solubility have more rapid dissolution rate that can accelerate the onset of drugs action. Other major barriers in oral drug delivery are p-glycoprotein efflux pumps and chemical or enzymatic degradation. Recent researches have shown that some specific lipids or surfactants, which are used in lipid nanoparticles, are capable of inhibiting p-glycoprotein efflux pumps. Drug-loaded lipid nanoparticles could reduce chemical or enzymatic degradation of the drugs which are embedded in a lipid matrix. Lipid nanoparticles could promote lymphatic transport and can bypass the liver and avoid hepatic first pass effect [50],[51],[52],[130],[131]. Lipid nanoparticles advantages and disadvantages for oral route are listed in [Table 3].
Table 3: Lipid nanoparticles advantages and disadvantages as oral drug delivery systems.

Click here to view

4.3. Ocular administration

Ocular drug delivery has many limitations and remains challenging because of specific physiological and anatomical features of the eyes. Eyes are a very complex and sophisticated organ and have several barriers that should be overcome in order to reach specific ocular tissue. Novel drug delivery systems such as lipid nanoparticles were considered to overcome these barriers and improve ocular tissue bioavailability. Topical application is the most common route of drug delivery to the anterior segment of the eyes. This route of administration has many advantages and is the choice for superficial ocular diseases. Major barriers in this pathway are corneal epithelium, blood ocular barrier, conjunctival blood flow, and tear drainage. Lipid nanoparticles which are used as ocular drug delivery systems are capable of passing blood ocular barrier, obtain sustained and controlled drug release, protect drugs from lacrimal enzymes and prolong drug deposition and residence time in eyes. Treatment of ocular diseases, which involve posterior segment of the eyes, is very difficult. There are different ways to target posterior segment of the eyes.

Topical route is not a suitable way to target intraocular tissues; other routes that are used for this purpose are transscleral delivery (subconjunctival and retrobulbar injection), intravitreal route, subretinal injection, etc. Most of these ways are invasive, so novel drug delivery systems such as lipid nanoparticles could be an appropriate alternative. Gene therapy for the purpose of retinal targeting in retinal diseases was also considered using non-viral vectors gene delivery including SLNs and NLCs [73],[74],[75],[76],[81]. A brief list of advantages and disadvantages of this route of administration are listed in [Table 4].
Table 4: Lipid nanoparticles advantages and disadvantages as ocular drug delivery systems.

Click here to view

4.4. Parenteral administration

Nanomedicine and nanotechnology play an important role in improving the parenteral drug delivery. Lipid nanoparticles advantages and disadvantages as parenteral drug delivery systems are listed in [Table 5]. The most important advantages of lipid nanoparticles for this purpose are ease of scale up production, biocompatible and biodegradable nature of the formulation constituents, controlled and modified drug release pattern, preventing drug degradation and maintaining more constant serum levels of drugs. Drug-loaded lipid nanoparticles may be injected intravenously, subcutaneously, intramuscularly, and directlyto target organs. Drug release from lipid nanoparticles may occur via erosion (such as enzymatic degradation) or via diffusion which could support a sustained drug release. Recent researches have confirmed the capability of lipid nanoparticles in peptide and protein incorporation. In this context, SLNs are not suitable carrier due to limited drug loading capacity but NLCs are appropriate alternative. In this method peptides and proteins can be protected from harsh environmental conditions [92],[93],[97],[100] .
Table 5: Lipid nanoparticles advantages and disadvantages as parenteral drug delivery systems.

Click here to view

4.5. Pulmonary delivery

Pulmonary drug delivery is a relatively new approach, which has many advantages. It is a non-invasive route of drug delivery for both local and systemic administration. By this direct delivery system, drug dosage may be decreased and consequently drug adverse effects would be reduced. Direct drug inhalation can also accelerate onset of action. High drug accumulation in target site is another advantage of such administration route. Large surface area of pulmonary system and thin alveolar epithelium could guarantee high drug permeability. Lipid microparticles were used as delivery systems for lung targeting. These particulate systems showed good results such as drug bioavailability enhancement in comparison with conventional formulations. Lipid nanoparticles including SLNs and NLCs have been considered for pulmonary delivery. They have the advantage of sustaining drug release, biocompatibility and biodegradablity, lower toxicity and better stability in comparison with previously designed particulate systems. Pulmonary delivery of drug-loaded nanoparticles would result in high local concentration and can reduce systemic adverse effects. Also nanoparticles can achieve higher bioavailability for systemic delivery purposes. Lipid nanoparticles used in lung drug delivery, like other routes of administration, have the advantage of sustained drug delivery [103],[114],[117],[118]. Some of the most important advantages and limitations of this route of administration are listed in [Table 6]a.
Table 6: Lipid nanoparticles advantages and disadvantages as pulmonary drug delivery systems.

Click here to view

4.6. Brain delivery

Drug delivery to the brain is one of the most important challenges in pharmaceutical sciences because of the presence of blood brain barrier (BBB). Nanoparticles with the advantage of small particle size and high drug encapsulation efficiency have been considered for specific targeting of brain tissues. Since nanoparticles can bypass reticuloendothelial system (RES), they are suitable as brain drug delivery systems. Two major obstacles in brain drug delivery are limited penetration of drugs across BBB and efflux of transported drugs from brain to blood circulation. Lipid nanoparticles such as SLNs and NLCs are one of the colloidal drug delivery systems that have been utilized to overcome these barriers. Lipid nanoparticles advantages and limitations as brain drug delivery systems are listed in [Table 7]. Lipid nanoparticles have the advantage of increasing drug retention time in blood of brain capillaries and inducing a drug gradient from blood to brain tissues, opening tight junctions to facilitate passage from BBB and transcytosis of drug-loaded lipid nanoparticles through the endothelium layer. Lipid nanoparticles are suitable for incorporating both lipophilic and hydrophilic drugs which could be administered via different routes [120],[121],[122],[123],[124],[125],[126],[127],[128],[129]. Previous researches emphasized on significant effect of surfactant suitability for brain drug delivery. Appropriate surfactants could be chosen according to their HLB and packing parameter. For site-specific brain drug delivery, polysorbates especially polysorbate 80, has shown best results. In addition, results showed that positively charged lipid nanoparticles induce better drug accumulation in the brain [123].
Table 7: Lipid nanoparticles advantages and disadvantages as brain drug delivery systems.

Click here to view

  5. Commercially Available Products from Lipid Nano-Particles in Market Top

Today, most of the commercially available products from lipid nanoparticles are cosmetic products such as Cutanova Cream Nano Repair Q10, Intensive Serum Nano Repair Q10, Cutanova Cream Nano Vital Q10, SURMER Crème Legère Nano-Protection, SURMER Crème Riche Nano-Restructurante, SURMER Elixir du Beauté Nano-Vitalisant, SURMER Masque Crème Nano-Hydratant, NanoLipid Restore CLR, NanoLipid Q10 CLR, NanoLipid Basic CLR, NanoLipid Repair CLR, IOPE SuperVital cream, serum, eye cream, extra moist softener and extra moist emulsion, NLC Deep Effect Eye Serum, NLC Deep Effect Repair Cream, NLC Deep Effect Reconstruction Cream, NLC Deep Effect Reconstruction Serum, Regenerations Creme Intensiv Scholl, Swiss Cellular White Illuminating Eye Essence, Swiss Cellular White Intensive Ampoules, SURMER Creme Contour Des Yeux Nano-Remodelante, Olivenöl Anti Falten Pflegekonzentrat, Olivenöl Augenpflegebalsam [18].

  6. Conclusion Top

lipid nanoparticles are novel drug deivery systems which have many advantages over other colloidal and polymeric nanocarriers. The most important advantages of lipid carriers are their biocompatibility, biodegradability, ease of scalability, and controlled and modified release patterns. Among these two types of lipid nanoparticles (SLN and NLC), NLCs as a second generation of lipid nanoparticles, has shown better results for the purpose of targeted drug delivery and nowadays are more considered for different routes of administration. Lipid nanoparticles are suitable carriers for both hydrophilic and lipophilic drugs. They can be administered by different routes such as topical, oral, parenteral, ocular, pulmonary, brain drug delivery. These nanoparticles for each routes of administration have its own advantages and also limitations that should be considered. Lipid nanoaprticles are promising drug delivery systems for delivery of various pharmaceutically important active ingredients from small molecule to protein and gene in early future.

  Acknowledgement Top

The content of this paper is taken from the Pharm.D thesis (Grant No. 95010511769) submitted by Parisa Ghasemiyeh and was financially supported by the vice chancellery research of Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

  References Top

MuÈller RH, Mader K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. Eur J Pharm Biopharm. 2000;50(1):161-177.  Back to cited text no. 1
Beloqui A, Solinis MA, Rodriguez-Gascon A, Almeida AJ, Preat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine. 2016;12(1):143-161.  Back to cited text no. 2
Luo Y, Chen D, Ren L, Zhao X, Qin J. Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. J Control Release. 2006;114(1):53-59.  Back to cited text no. 3
Silva A, González-Mira E, García ML, Egea MA, Fonseca J, Silva R, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces. 2011;86(1):158-165.   Back to cited text no. 4
Schwarz C, Mehnert W, Lucks JS, Müller RH. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J. Control. Release. 1994;30(1):83-96.  Back to cited text no. 5
zur Mühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery–drug release and release mechanism. Eur J Pharm Biopharm. 1998;45(2):149-155.  Back to cited text no. 6
Wang X, Chen H, Luo Z, Fu X. Preparation of starch nanoparticles in water in oil microemulsion system and their drug delivery properties. Carbohydr Polym. 2016;138:192-200.  Back to cited text no. 7
Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12(11):1561-1572.  Back to cited text no. 8
Doktorovova S, Kovacevic AB, Garcia ML, Souto EB. Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation. Eur J Pharm Biopharm. 2016;108:235-252  Back to cited text no. 9
Yoon G, Park JW, Yoon IS. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. J Pharm Investig. 2013;43(5):353-362.  Back to cited text no. 10
Makwana V, Jain R, Patel K, Nivsarkar M, Joshi A. Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: Elucidation of mechanism of uptake using chylomicron flow blocking approach. Int J Pharm. 2015;495(1):439-446.  Back to cited text no. 11
Shidhaye SS, Vaidya R, Sutar S, Patwardhan A, Kadam VJ. Solid lipid nanoparticles and nanostructured lipid carriers-innovative generations of solid lipid carriers. Curr Drug Deliv. 2008;5(4):324-231.  Back to cited text no. 12
Kasongo KW, Muller RH, Walker RB. The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients. Pharm Dev Technol. 2012;17(3):353-362.  Back to cited text no. 13
Souto EB, Müller RH. Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization. J Microencapsul. 2006;23(4):377-388.  Back to cited text no. 14
Chen DB, Yang TZ, Lu WL, Zhang Q. In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. Chem Pharm Bull (Tokyo). 2001;49(11):1444-1447.  Back to cited text no. 15
Mojahedian MM, Daneshamouz S, Samani SM, Zargaran A. A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique. Chem Phys Lipids. 2013;174:32-38.  Back to cited text no. 16
Souto EB, Wissing SA, Barbosa CM, Müller RH. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm. 2004;278(1):71-77.  Back to cited text no. 17
Pardeike J, Hommoss A, Muller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm. 2009;366(1-2):170-184.  Back to cited text no. 18
Shah RM, Malherbe F, Eldridge D, Palombo EA, Harding IH. Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. J. Colloid Interface Sci. 2014;428:286-294.  Back to cited text no. 19
Gainza G, Pastor M, Aguirre JJ, Villullas S, Pedraz JL, Hernandez RM, et al. A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: In vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice. J Control Release. 2014;185:51-61.  Back to cited text no. 20
Vitorino C, Almeida A, Sousa J, Lamarche I, Gobin P, Marchand S, et al. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies. Eur J Pharm Biopharm. 2014;86(2):133-144.  Back to cited text no. 21
Gainza G, Bonafonte DC, Moreno B, Aguirre JJ, Gutierrez FB, Villullas S, et al. The topical administration of rhEGF-loaded nanostructured lipid carriers (rhEGF-NLC) improves healing in a porcine full-thickness excisional wound model. J Control Release. 2015;197:41-47.  Back to cited text no. 22
Nnamani PO, Hansen S, Windbergs M, Lehr CM. Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application. Int J Pharm. 2014;477(1-2):208-217.  Back to cited text no. 23
Park JH, Ban SJ, Ahmed T, Choi HS, Yoon HE, Yoon JH, et al. Development of DH-I-180-3 loaded lipid nanoparticle for photodynamic therapy. Int J Pharm. 2015;491(1-2):393-401.  Back to cited text no. 24
Ferreira M, Silva E, Barreiros L, Segundo MA, Lima CSA, Reis S. Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential. Int J Pharm. 2016;512(1):14-21.  Back to cited text no. 25
Jain AK, Jain A, Garg NK, Agarwal A, Jain A, Jain SA, et al. Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids Surf B Biointerfaces. 2014;121:222-229.  Back to cited text no. 26
Butani D, Yewale C, Misra A. Topical Amphotericin B solid lipid nanoparticles: Design and development. Colloids Surf B Biointerfaces. 2016;139:17-24.  Back to cited text no. 27
Lohan SB, Bauersachs S, Ahlberg S, Baisaeng N, Keck CM, Muller RH, et al. Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress. Eur J Pharm Biopharm. 2015;89:201-207.  Back to cited text no. 28
Chen J, Wei N, Lopez-Garcia M, Ambrose D, Lee J, Annelin C, et al. Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications. Eur J Pharm Biopharm. 2017;117:286-291.  Back to cited text no. 29
Jenning V, Gysler A, Schäfer-Korting M, Gohla SH. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm. 2000;49(3):211-218.  Back to cited text no. 30
Stecova J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, et al. Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake. Pharm Res. 2007;24(5):991-1000.  Back to cited text no. 31
Üner M, Karaman EF, Aydoğmuş Z. Solid lipid nanoparticles and nanostructured lipid carriers of loratadine for topical application: physicochemical stability and drug penetration through rat skin. Trop J Pharm Res. 2014;13(5):653-660.  Back to cited text no. 32
Bikkad ML, Nathani AH, Mandlik SK, Shrotriya SN, Ranpise NS. Halobetasol propionate-loaded solid lipid nanoparticles (SLN) for skin targeting by topical delivery. J Liposome Res. 2014;24(2):113-123.  Back to cited text no. 33
Charoenputtakhun P, Opanasopit P, Rojanarata T, Ngawhirunpat T. All-trans retinoic acid-loaded lipid nanoparticles as a transdermal drug delivery carrier. Pharm Dev Technol. 2014;19(2):164-172.  Back to cited text no. 34
Desmet E, Van Gele M, Lambert J. Topically applied lipid- and surfactant-based nanoparticles in the treatment of skin disorders. Expert Opin Drug Deliv. 2017;14(1):109-122.  Back to cited text no. 35
Lauterbach A, Muller-Goymann CC. Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route. Eur J Pharm Biopharm. 2015;97(Pt A):152-163.  Back to cited text no. 36
Müller RH, Staufenbiel S, Keck CM. Lipid nanoparticles (SLN, NLC) for innovative consumer care and household products. H and PC Today. 2014;9(2):18-25.  Back to cited text no. 37
Gonullu U, Uner M, Yener G, Karaman EF, Aydogmus Z. Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery. Acta Pharm. 2015;65(1):1-13.  Back to cited text no. 38
Hamishehkar H, Shokri J, Fallahi S, Jahangiri A, Ghanbarzadeh S, Kouhsoltani M. Histopathological evaluation of caffeine-loaded solid lipid nanoparticles in efficient treatment of cellulite. Drug Dev Ind Pharm. 2015;41(10):1640-1646.  Back to cited text no. 39
Marto J, Sangalli C, Capra P, Perugini P, Ascenso A, Goncalves L, et al. Development and characterization of new and scalable topical formulations containing N-acetyl-d-glucosamine-loaded solid lipid nanoparticles. Drug Dev Ind Pharm. 2017;43(11):1792-1800.  Back to cited text no. 40
Puglia C, Bonina F. Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert Opin Drug Deliv. 2012;9(4):429-241.  Back to cited text no. 41
Puglia C, Lauro MR, Offerta A, Crasci L, Micicche L, Panico AM, et al. Nanostructured lipid carriers (NLC) as vehicles for topical administration of sesamol: in vitro percutaneous absorption study and evaluation of antioxidant activity. Planta Med. 2017;83(5):398-404.  Back to cited text no. 42
Puglia C, Offerta A, Tirendi GG, Tarico MS, Curreri S, Bonina F, et al. Design of solid lipid nanoparticles for caffeine topical administration. Drug Deliv. 2016;23(1):36-40.  Back to cited text no. 43
Teeranachaideekul V, Chantaburanan T, Junyaprasert VB. Influence of state and crystallinity of lipid matrix on physicochemical properties and permeation of capsaicin-loaded lipid nanoparticles for topical delivery. J Drug Deliv Sci Technol. 2017;39:300-307.  Back to cited text no. 44
Muller RH, Runge S, Ravelli V, Mehnert W, Thunemann AF, Souto EB. Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals. Int J Pharm. 2006;317(1):82-89.  Back to cited text no. 45
Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B, Wiwattanapatapee R. Modification of oral absorption of oxyresveratrol using lipid based nanoparticles. Colloids Surf B Biointerfaces. 2015;131:182-190.  Back to cited text no. 46
Zhuang CY, Li N, Wang M, Zhang XN, Pan WS, Peng JJ, et al. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm. 2010;394(1-2):179-185.  Back to cited text no. 47
Shangguan M, Qi J, Lu Y, Wu W. Comparison of the oral bioavailability of silymarin-loaded lipid nanoparticles with their artificial lipolysate counterparts: implications on the contribution of integral structure. Int J Pharm. 2015;489(1-2):195-202.  Back to cited text no. 48
Zhang Y, Li Z, Zhang K, Yang G, Wang Z, Zhao J, et al. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans -ferulic acid ascompared with conventional solid lipid nanoparticles. Int J Pharm. 2016;511(1):57-64.  Back to cited text no. 49
Garg A, Bhalala K, Tomar DS, Wahajuddin. In-situ single pass intestinal permeability and pharmacokinetic study of developed Lumefantrine loaded solid lipid nanoparticles. Int J Pharm. 2017;516(1-2):120-30.  Back to cited text no. 50
Cirri M, Mennini N, Maestrelli F, Mura P, Ghelardini C, Mannelli DCL. Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics. Int J Pharm. 2017;521(1-2):73-83.  Back to cited text no. 51
Luan J, Zheng F, Yang X, Yu A, Zhai G. Nanostructured lipid carriers for oral delivery of baicalin: In vitro and in vivo evaluation. Colloids Surf. A. 2015;466:154-159.  Back to cited text no. 52
Mendes AI, Silva AC, Catita JA, Cerqueira F, Gabriel C, Lopes CM. Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity. Colloids Surf B Biointerfaces. 2013;111:755-763.  Back to cited text no. 53
Ranpise NS, Korabu SS, Ghodake VN. Second generation lipid nanoparticles (NLC) as an oral drug carrier for delivery of lercanidipine hydrochloride. Colloids Surf B Biointerfaces. 2014;116:81-87.  Back to cited text no. 54
Ravi PR, Aditya N, Kathuria H, Malekar S, Vats R. Lipid nanoparticles for oral delivery of raloxifene: optimization, stability, in vivo evaluation and uptake mechanism. Eur J Pharm Biopharm. 2014;87(1):114-124.  Back to cited text no. 55
Patil-Gadhe A, Pokharkar V. Montelukast-loaded nanostructured lipid carriers: part I oral bioavailability improvement. Eur J Pharm Biopharm. 2014;88(1):160-168.  Back to cited text no. 56
Goncalves LMd, Maestrelli F, Mannelli DCL, Ghelardini C, Almeida AJ, Mura P. Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. Eur J Pharm Biopharm. 2016;102:41-50.  Back to cited text no. 57
Pandita D, Kumar S, Poonia N, Lather V. Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol. Food Res Int. 2014;62:1165-1174.  Back to cited text no. 58
Desai PP, Date AA, Patravale VB. Overcoming poor oral bioavailability using nanoparticle formulations - opportunities and limitations. Drug Discov Today Technol. 2012;9(2):e71-e174.  Back to cited text no. 59
Beloqui A, Solinis MA, Delgado A, Evora C, Isla A, Rodriguez-Gascon A. Fate of nanostructured lipid carriers (NLCs) following the oral route: design, pharmacokinetics and biodistribution. J Microencapsul. 2014;31(1):1-8.  Back to cited text no. 60
Shah MK. Solid lipid nanoparticles (SLN) for oral drug delivery: an overview. J Nanomed Nanosci. 2017.  Back to cited text no. 61
Muchow M, Maincent P, Müller RH. Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug Dev Ind Pharm. 2008;34(12):1394-1405.  Back to cited text no. 62
Nunes S, Madureira AR, Campos D, Sarmento B, Gomes AM, Pintado M, et al. Solid lipid nanoparticles as oral delivery systems of phenolic compounds: Overcoming pharmacokinetic limitations for nutraceutical applications. Crit Rev Food Sci Nutr. 2017;57(9):1863-1873.  Back to cited text no. 63
Rao S, Prestidge CA. Polymer-lipid hybrid systems: merging the benefits of polymeric and lipid-based nanocarriers to improve oral drug delivery. Expert Opin Drug Deliv. 2016;13(5):691-707.  Back to cited text no. 64
Leonardi A, Bucolo C, Romano GL, Platania CB, Drago F, Puglisi G, et al. Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles. Int J Pharm. 2014;470(1-2):133-140.  Back to cited text no. 65
Attama AA, Reichl S, Müller-Goymann CC. Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct. International journal of pharmaceutics. 2008;355(1-2):307-313.  Back to cited text no. 66
Li X, Nie Sf, Kong J, Li N, Ju CY, Pan WS. A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers. Int J Pharm. 2008;363(1-2):177-182.  Back to cited text no. 67
Luo Q, Zhao J, Zhang X, Pan W. Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm. 2011;403(1-2):185-191.  Back to cited text no. 68
Araújo J, Gonzalez E, Egea MA, Garcia ML, Souto EB. Nanomedicines for ocular NSAIDs: safety on drug delivery. Nanomedicine. 2009;5(4):394-401.  Back to cited text no. 69
Araújo J, Gonzalez-Mira E, Egea MA, Garcia ML, Souto EB. Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications. Int J Pharm. 2010;393(1-2):167-75.  Back to cited text no. 70
Fangueiro JF, Andreani T, Egea MA, Garcia ML, Souto SB, Silva AM, et al. Design of cationic lipid nanoparticles for ocular delivery: development, characterization and cytotoxicity. Int J Pharm. 2014;461(1-2):64-73.  Back to cited text no. 71
Balguri SP, Adelli GR, Janga KY, Bhagav P, Majumdar S. Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol. Int J Pharm.. 2017;529(1-2):32-43.  Back to cited text no. 72
Balguri SP, Adelli GR, Majumdar S. Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues. Eur J Pharm Biopharm. 2016;109:224-235.  Back to cited text no. 73
Chetoni P, Burgalassi S, Monti D, Tampucci S, Tullio V, Cuffini AM, et al. Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits. Eur J Pharm Biopharm. 2016;109:214-223.  Back to cited text no. 74
Sánchez-López E, Espina M, Doktorovova S, Souto EB, García ML. Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye - Part I - Barriers and determining factors in ocular delivery. Eur J Pharm Biopharm. 2017;110:70-75.  Back to cited text no. 75
Sánchez-López E, Espina M, Doktorovova S, Souto EB, García ML. Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye - Part II - Ocular drug-loaded lipid nanoparticles. Eur J Pharm Biopharm. 2017;110:58-69.  Back to cited text no. 76
Liu D, Li J, Cheng B, Wu Q, Pan H. Ex Vivo and in Vivo evaluation of the effect of coating a coumarin-6-labeled nanostructured lipid carrier with chitosan-N-acetylcysteine on rabbit ocular distribution. Mol Pharm. 2017;14(8):2639-2648.  Back to cited text no. 77
Almeida H, Amaral MH, Lobão P, Silva AC, Loboa JM. Applications of polymeric and lipid nanoparticles in ophthalmic pharmaceutical formulations: present and future considerations. J Pharm Pharm Sci. 2014;17(3):278-293.  Back to cited text no. 78
Andrade LM, Rocha KA, De Sá FA, Marreto RN, Lima EM, Gratieri T, et al. Voriconazole-loaded nanostructured lipid carriers for ocular drug delivery. Cornea. 2016;35(6):866-871.  Back to cited text no. 79
Basaran E, Demirel M, Sirmagül B, Yazan Y. Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery. J Microencapsul. 2010;27(1):37-47.  Back to cited text no. 80
Battaglia L, Serpe L, Foglietta F, Muntoni E, Gallarate M, Rodriguez DPA, et al. Application of lipid nanoparticles to ocular drug delivery. Expert Opin Drug Deliv. 2016;13(12):1743-1757.  Back to cited text no. 81
Seyfoddin A, Shaw J, Al-Kassas R. Solid lipid nanoparticles for ocular drug delivery. Drug Deliv. 2010;17(7):467-489.  Back to cited text no. 82
Souto EB, Doktorovova S, Gonzalez-Mira E, Egea MA, Garcia ML. Feasibility of lipid nanoparticles for ocular delivery of anti-inflammatory drugs. Curr Eye Res. 2010;35(7):537-552.  Back to cited text no. 83
Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev. 2004;56(9):1257-1272.  Back to cited text no. 84
Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 2007;59(6):478-490.  Back to cited text no. 85
Wong HL, Bendayan R, Rauth AM, Li Y, Wu XY. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 2007;59(6):491-504.  Back to cited text no. 86
Hommoss G, Pyo SM, Müller RH. Mucoadhesive tetrahydrocannabinol-loaded NLC - Formulation optimization and long-term physicochemical stability. Eur J Pharm Biopharm. 2017;117:408-417.  Back to cited text no. 87
Muller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs--a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol. 2004;113(1-3):151-170.  Back to cited text no. 88
Kim JK, Park JS, Kim CK. Development of a binary lipid nanoparticles formulation of itraconazole for parenteral administration and controlled release. Int J Pharm. 2010;383(1-2):209-215.  Back to cited text no. 89
Bhise K, Kashaw SK, Sau S, Iyer AK. Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach. Int J Pharm. 2017;526(1-2):506-515.  Back to cited text no. 90
Jia L, Zhang D, Li Z, Duan C, Wang Y, Feng F, et al. Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies. Colloids Surf B Biointerfaces. 2010;80(2):213-218.  Back to cited text no. 91
Liu D, Liu Z, Wang L, Zhang C, Zhang N. Nanostructured lipid carriers as novel carrier for parenteral delivery of docetaxel. Colloids Surf B Biointerfaces. 2011;85(2):262-269.  Back to cited text no. 92
Luan J, Zhang D, Hao L, Qi L, Liu X, Guo H, et al. Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers. Colloids and surfaces B, Biointerfaces. 2014;114:255-60.  Back to cited text no. 93
Joshi MD, Müller RH. Lipid nanoparticles for parenteral delivery of actives. Eur J Pharm Biopharm. 2009;71(2):161-172.  Back to cited text no. 94
Ajorlou E, Khosroushahi AY. Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors. Cancer Chemother Pharmacol. 2017;79(2):251-265.  Back to cited text no. 95
Mussi SV, Sawant R, Perche F, Oliveira MC, Azevedo RB, Ferreira LA, et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. Pharm Res. 2014;31(8):1882-1892.  Back to cited text no. 96
Chinsriwongkul A, Chareanputtakhun P, Ngawhirunpat T, Rojanarata T, Sila-on W, Ruktanonchai U, et al. Nanostructured lipid carriers (NLC) for parenteral delivery of an anticancer drug. AAPS PharmSciTech. 2012;13(1):150-158.  Back to cited text no. 97
Wu M, Fan Y, Lv S, Xiao B, Ye M, Zhu X. Vincristine and temozolomide combined chemotherapy for the treatment of glioma: a comparison of solid lipid nanoparticles and nanostructured lipid carriers for dual drugs delivery. Drug Deliv. 2016;23(8):2720-2725.  Back to cited text no. 98
Martins S, Sarmento B, Ferreira DC, Souto EB. Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles. Int J Nanomedicine. 2007;2(4):595-607.  Back to cited text no. 99
Qureshi OS, Kim HS, Zeb A, Choi JS, Kim HS, Kwon JE, et al. Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration. J Microencapsul. 2017;34(3):250-261.  Back to cited text no. 100
Zeb A, Qureshi OS, Kim HS, Kim MS, Kang JH, Park JS, et al. High payload itraconazole-incorporated lipid nanoparticles with modulated release property for oral and parenteral administration. J Pharm Pharmacol. 2017;69(8):955-966.  Back to cited text no. 101
Ahmadnia S, Moazeni M, Mohammadi-Samani S, Oryan A. In vivo evaluation of the efficacy of albendazole sulfoxide and albendazole sulfoxide loaded solid lipid nanoparticles against hydatid cyst. Exp Parasitol. 2013;135(2):314-319.  Back to cited text no. 102
Cipolla D, Shekunov B, Blanchard J, Hickey A. Lipid-based carriers for pulmonary products: preclinical development and case studies in humans. Adv Drug Deliv Rev. 2014;75:53-80.  Back to cited text no. 103
Taratula O, Kuzmov A, Shah M, Garbuzenko OB, Minko T. Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA. J Control Release. 2013;171(3):349-357.  Back to cited text no. 104
Pardeike J, Weber S, Haber T, Wagner J, Zarfl HP, Plank H, et al. Development of an itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application. Int J Pharm. 2011;419(1-2):329-338.  Back to cited text no. 105
Patil-Gadhe A, Kyadarkunte A, Patole M, Pokharkar V. Montelukast-loaded nanostructured lipid carriers: part II pulmonary drug delivery and in vitro-in vivo aerosol performance. Eur J Pharm Biopharm. 2014;88(1):169-177.  Back to cited text no. 106
Patil-Gadhe A, Pokharkar V. Pulmonary targeting potential of rosuvastatin loaded nanostructured lipid carrier: Optimization by factorial design. Int J Pharm. 2016;501(1-2):199-210.  Back to cited text no. 107
Hidalgo A, Cruz A, Perez-Gil J. Barrier or carrier? Pulmonary surfactant and drug delivery. Eur J Pharm Biopharm. 2015;95(Pt A):117-127.  Back to cited text no. 108
Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release. 2010;144(2):233-241.  Back to cited text no. 109
Nafee N, Husari A, Maurer CK, Lu C, de Rossi C, Steinbach A, et al. Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors. J Control Release. 2014;192:131-140.  Back to cited text no. 110
Paranjpe M, Finke JH, Richter C, Gothsch T, Kwade A, Buttgenbach S, et al. Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application. Int J Pharm. 2014;476(1-2):41-49.  Back to cited text no. 111
Moreno-Sastre M, Pastor M, Esquisabel A, Sans E, Vinas M, Fleischer A, et al. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm. 2016;498(1-2):263-273.  Back to cited text no. 112
Zhao Y, Chang YX, Hu X, Liu CY, Quan LH, Liao YH. Solid lipid nanoparticles for sustained pulmonary delivery of Yuxingcao essential oil: Preparation, characterization and in vivo evaluation. Int J Pharm. 2017;516(1-2):364-371.  Back to cited text no. 113
Makled S, Nafee N, Boraie N. Nebulized solid lipid nanoparticles for the potential treatment of pulmonary hypertension via targeted delivery of phosphodiesterase-5-inhibitor. Int J Pharm. 2017;517(1-2):312-321.  Back to cited text no. 114
Islan GA, Tornello PC, Abraham GA, Duran N, Castro GR. Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery. Design and characterization. Colloids Surf B Biointerfaces. 2016;143:168-176.  Back to cited text no. 115
Weber S, Zimmer A, Pardeike J. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharm Biopharm. 2014;86(1):7-22.  Back to cited text no. 116
Pardeike J, Weber S, Zarfl HP, Pagitz M, Zimmer A. Itraconazole-loaded nanostructured lipid carriers (NLC) for pulmonary treatment of aspergillosis in falcons. Eur J Pharm Biopharm. 2016;108:269-276.  Back to cited text no. 117
Kaur P, Garg T, Rath G, Murthy RS, Goyal AK. Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design. Drug Deliv. 2016;23(6):1912-125.  Back to cited text no. 118
Paranjpe M, Muller-Goymann CC. Nanoparticle-mediated pulmonary drug delivery: a review. Int J Mol Sci. 2014;15(4):5852-5873.  Back to cited text no. 119
Kaur IP, Bhandari R, Bhandari S, Kakkar V. Potential of solid lipid nanoparticles in brain targeting. J Control Release. 2008;127(2):97-109.  Back to cited text no. 120
Dal Magro R, Ornaghi F, Cambianica I, Beretta S, Re F, Musicanti C, et al. ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier. J Control Release. 2017;249:103-110.  Back to cited text no. 121
Blasi P, Giovagnoli S, Schoubben A, Puglia C, Bonina F, Rossi C, et al. Lipid nanoparticles for brain targeting I. Formulation optimization. Int J Pharm. 2011;419(1-2):287-295.  Back to cited text no. 122
Blasi P, Giovagnoli S, Schoubben A, Ricci M, Rossi C. Solid lipid nanoparticles for targeted brain drug delivery. Adv Drug Deliv Rev. 2007;59(6):454-477.  Back to cited text no. 123
Blasi P, Schoubben A, Romano GV, Giovagnoli S, Michele DA, Ricci M. Lipid nanoparticles for brain targeting II. Technological characterization. Colloids Surf B Biointerfaces. 2013;110:130-137.  Back to cited text no. 124
Blasi P, Schoubben A, Traina G, Manfroni G, Barberini L, Alberti PF, et al. Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity. Int J Pharm. 2013;454(1):316-323.  Back to cited text no. 125
Gastaldi L, Battaglia L, Peira E, Chirio D, Muntoni E, Solazzi I, et al. Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art. Eur J Pharm Biopharm. 2014;87(3):433-444.  Back to cited text no. 126
Montenegro L, Campisi A, Sarpietro MG, Carbone C, Acquaviva R, Raciti G, et al. In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain. Drug Dev Ind Pharm. 2011;37(6):737-746.  Back to cited text no. 127
Patel S, Chavhan S, Soni H, Babbar AK, Mathur R, Mishra AK, et al. Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. J Drug Target 2011;19(6):468-474.  Back to cited text no. 128
Tosi G, Musumeci T, Ruozi B, Carbone C, Belletti D, Pignatello R, et al. The “fate” of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system. J Drug Deliv Sci Technol. 2016;32:66-76.  Back to cited text no. 129
Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MH, Silva AM, et al. Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv. 2012;2012:1-10.  Back to cited text no. 130
Tran TH, Ramasamy T, Truong DH, Choi HG, Yong CS, Kim JO. Preparation and characterization of fenofibrate-loaded nanostructured lipid carriers for oral bioavailability enhancement. AAPS PharmSciTech. 2014;15(6):1509-1515.  Back to cited text no. 131
Khan S, Baboota S, Ali J, Khan S, Narang RS, Narang JK. Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs. Int J Pharm Investig. 2015;5(4):182-191.  Back to cited text no. 132
Hosseini M, Haji-Fatahaliha M, Jadidi-Niaragh F, Majidi J, Yousefi M. The use of nanoparticles as a promising therapeutic approach in cancer immunotherapy. Artif Cells Nanomed Biotechnol. 2016;44(4):1051-1061.  Back to cited text no. 133
Attama AA. SLN, NLC, LDC: state of the art in drug and active delivery. Recent Pat Drug Deliv Formul. 2011;5(3):178-187.  Back to cited text no. 134
Selvamuthukumar S, Velmurugan R. Nanostructured lipid carriers: a potential drug carrier for cancer chemotherapy. Lipids Health Dis. 2012;11(1):159-166.  Back to cited text no. 135
Prasad D, Chauhan H. Nanotoxicity of Polymeric and Solid Lipid Nanoparticles. In:. Sutariya VB, Pathak Y, editors. Biointeractions of Nanomaterials. Florida: CRC Press; 2014. pp. 151.  Back to cited text no. 136
Xiang QY, Wang MT, Chen F, Gong T, Jian YL, Zhang ZR, et al. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch Pharm Res. 2007;30(4):519-525.  Back to cited text no. 137


  [Figure 1]

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7]

This article has been cited by
1 Chitosan oligosaccharide/alginate nanoparticles as an effective carrier for astaxanthin with improving stability, in vitro oral bioaccessibility, and bioavailability
Feuangthit Niyamissara Sorasitthiyanukarn,Chawanphat Muangnoi,Pornchai Rojsitthisak,Pranee Rojsitthisak
Food Hydrocolloids. 2022; 124: 107246
[Pubmed] | [DOI]
2 Lipid nanostructures for targeting brain cancer
Hamdi Nsairat,Dima Khater,Fadwa Odeh,Fedaa Al-Adaileh,Suma Al-Taher,Areej M. Jaber,Walhan Alshaer,Abeer Al Bawab,Mohammad S. Mubarak
Heliyon. 2021; 7(9): e07994
[Pubmed] | [DOI]
3 Antibody Conjugated Lipid Nanoparticles as a Targeted Drug Delivery System for Hydrophobic Pharmaceuticals
Martine K. Notabi,Eva C. Arnspang,Morten Ø. Andersen
European Journal of Pharmaceutical Sciences. 2021; : 105777
[Pubmed] | [DOI]
4 Recent advances in encapsulation technologies of kenaf (Hibiscus cannabinus) leaves and seeds for cosmeceutical application
Chee Chin Chu,Sook Chin Chew,Kar Lin Nyam
Food and Bioproducts Processing. 2021;
[Pubmed] | [DOI]
5 Bioactive glass: A multifunctional delivery system
Smriti Gupta,Shreyasi Majumdar,Sairam Krishnamurthy
Journal of Controlled Release. 2021;
[Pubmed] | [DOI]
6 Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies
Akbar Hasanzadeh,Masoomeh Alamdaran,Sepideh Ahmadi,Helena Nourizadeh,Mohammad Aref Bagherzadeh,Mirza Ali Mofazzal Jahromi,Perikles Simon,Mahdi Karimi,Michael R. Hamblin
Journal of Controlled Release. 2021;
[Pubmed] | [DOI]
7 Lipid nanoparticles with improved biopharmaceutical attributes for tuberculosis treatment
Aldemar Gordillo-Galeano,Luis Fernando Ospina-Giraldo,Claudia Elizabeth Mora-Huertas
International Journal of Pharmaceutics. 2021; 596: 120321
[Pubmed] | [DOI]
8 Vegetable oils in pharmaceutical and cosmetic lipid-based nanocarriers preparations
Jéssica Fagionato Masiero,Eduardo José Barbosa,Luiza de Oliveira Macedo,Aline de Souza,Megumi Nishitani Yukuyama,Geraldo José Arantes,Nádia Araci Bou-Chacra
Industrial Crops and Products. 2021; 170: 113838
[Pubmed] | [DOI]
9 Combination antipsychotics therapy for schizophrenia and related psychotic disorders interventions: Emergence to nanotechnology and herbal drugs
Akram Annu,Sanjula Baboota,Javed Ali
Journal of Drug Delivery Science and Technology. 2021; 61: 102272
[Pubmed] | [DOI]
10 Nose to brain delivery of Rotigotine loaded solid lipid nanoparticles: Quality by Design based optimization and characterization
Jagruti B. Prajapati,Gayatri C. Patel
Journal of Drug Delivery Science and Technology. 2021; : 102377
[Pubmed] | [DOI]
11 Understanding the implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer
Aditi Fulfager,Khushwant S. Yadav
Journal of Drug Delivery Science and Technology. 2021; : 102405
[Pubmed] | [DOI]
12 Recent updates in COVID-19 with emphasis on inhalation therapeutics: nanostructured and targeting systems
Ahmed A.H. Abdellatif,Hesham M. Tawfeek,Ahmed Abdelfattah,Gaber El-Saber Batiha,Helal F. Hetta
Journal of Drug Delivery Science and Technology. 2021; : 102435
[Pubmed] | [DOI]
13 Ceftriaxone sodium loaded onto polymer-lipid hybrid nanoparticles enhances antibacterial effect on gram-negative and gram-positive bacteria: Effects of lipid - polymer ratio on particles size, characteristics, in vitro drug release and antibacterial drug efficacy
Arash Rigi Hossein abadi,Nafiseh Farhadian,Mohammad Karimi,Samaneh Porozan
Journal of Drug Delivery Science and Technology. 2021; : 102457
[Pubmed] | [DOI]
14 Lymphatic transport system to circumvent hepatic metabolism for oral delivery of lipid-based nanocarriers
Amarjitsing Rajput, Prashant Pingale, Darshan Telange, Shailesh Chalikwar, Vivek Borse
Journal of Drug Delivery Science and Technology. 2021; 66: 102934
[Pubmed] | [DOI]
15 Herbal medicine for ocular diseases: An age old therapy and its future perspective
Archana S. Pokkalath, Apurva Sawant, Sujata P. Sawarkar
Journal of Drug Delivery Science and Technology. 2021; : 102979
[Pubmed] | [DOI]
16 Breaking the barriers for the delivery of amikacin: Challenges, strategies, and opportunities
Amala Maxwell,Vivek Ghate,Jesil Aranjani,Shaila Lewis
Life Sciences. 2021; : 119883
[Pubmed] | [DOI]
17 Investigating natural antibiofilm components: a new therapeutic perspective against candidal vulvovaginitis
Nazia Hassan,Salma Firdaus,Santwana Padhi,Asgar Ali,Zeenat Iqbal
Medical Hypotheses. 2021; : 110515
[Pubmed] | [DOI]
18 Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment
Sónia Rocha,Mariana Lucas,Daniela Ribeiro,M. Luísa Corvo,Eduarda Fernandes,Marisa Freitas
Pharmacological Research. 2021; 169: 105604
[Pubmed] | [DOI]
19 Preparation a core-shell lipid/polymer nanoparticle containing Isotretinoin drug with pH sensitive property: A response surface methodology study
Tahereh Najafi Ghaghelestani,Nafiseh Farhadian,Nafiseh Binesh
Journal of Applied Polymer Science. 2021; : 50734
[Pubmed] | [DOI]
20 Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity
Yusuf A. Haggag,Ahmed Kh. Abosalha,Murtaza M. Tambuwala,Enass Y. Osman,Sanaa A. El-Gizawy,Ebtessam A. Essa,Ahmed A. Donia
Biopharmaceutics & Drug Disposition. 2021;
[Pubmed] | [DOI]
21 A Film-Forming System Hybridized with a Nanostructured Chloroacetamide Derivative for Dermatophytosis Treatment
Gabriella R. M. Machado,Luiz A. M. Inácio,Simone J. Berlitz,Bruna Pippi,Irene C. Kulkamp-Guerreiro,Stefânia N. Lavorato,Ricardo J. Alves,Saulo F. Andrade,Alexandre M. Fuentefria
ChemistrySelect. 2021; 6(33): 8527
[Pubmed] | [DOI]
22 Lipid nanoparticles for the transport of drugs like dopamine through the blood-brain barrier
Elena Ortega,Santos Blanco,Adolfina Ruiz,María Ángeles Peinado,Sebastián Peralta,María Encarnación Morales
Journal of Nanoparticle Research. 2021; 23(4)
[Pubmed] | [DOI]
23 Nano-fats for bugs: the benefits of lipid nanoparticles for antimicrobial therapy
Chelsea R. Thorn,Nicky Thomas,Ben J. Boyd,Clive A. Prestidge
Drug Delivery and Translational Research. 2021;
[Pubmed] | [DOI]
24 The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems
Yinghao Zheng,Yun Wang,Mengyu Xia,Ya Gao,Lan Zhang,Yanan Song,Cun Zhang
Drug Delivery and Translational Research. 2021;
[Pubmed] | [DOI]
25 Nanomedicine-based antimicrobial peptide delivery for bacterial infections: recent advances and future prospects
Raj Kumar Thapa,Dzung B. Diep,Hanne Hjorth Tønnesen
Journal of Pharmaceutical Investigation. 2021;
[Pubmed] | [DOI]
26 Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches
Manasa Manjunath Hegde, Suma Prabhu, Srinivas Mutalik, Abhishek Chatterjee, Jayant S. Goda, B. S. Satish Rao
Journal of Pharmaceutical Investigation. 2021;
[Pubmed] | [DOI]
27 Nanotechnology-based Delivery of CRISPR/Cas9 for Cancer Treatment
Xiaoyu Xu,Chang Liu,Yonghui Wang,Oliver Koivisto,Junnian Zhou,Yilai Shu,Hongbo Zhang
Advanced Drug Delivery Reviews. 2021; : 113891
[Pubmed] | [DOI]
28 Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies
Cláudia Pina Costa,João Nuno Moreira,José Manuel Sousa Lobo,Ana Catarina Silva
Acta Pharmaceutica Sinica B. 2021;
[Pubmed] | [DOI]
29 Nanomedicines: Redefining traditional medicine
Weijia Lu,Jing Yao,Xiao Zhu,Yi Qi
Biomedicine & Pharmacotherapy. 2021; 134: 111103
[Pubmed] | [DOI]
30 Auraptene nanoparticles ameliorate testosterone-induced benign prostatic hyperplasia in rats: Emphasis on antioxidant, anti-inflammatory, proapoptotic and PPARs activation effects
Haifa Almukadi,Basma G. Eid,Rasheed A. Shaik,Ashraf B. Abdel-Naim,Ahmed Esmat
Biomedicine & Pharmacotherapy. 2021; 143: 112199
[Pubmed] | [DOI]
31 Structured edible lipid-based particle systems for oral drug-delivery
Areen Ashkar,Alejandro Sosnik,Maya Davidovich-Pinhas
Biotechnology Advances. 2021; : 107789
[Pubmed] | [DOI]
32 Prospects and challenges of anticancer agentsæ delivery via chitosan-based drug carriers to combat breast cancer: A review
Guiqiu Wang,Rilun Li,Benyamin Parseh,Gang Du
Carbohydrate Polymers. 2021; : 118192
[Pubmed] | [DOI]
33 Biomaterials for Orthopaedic Diagnostics and Theranostics
Marian A. Ackun-Farmmer,Clyde T. Overby,Brittany E. Haws,Regine Choe,Danielle S.W. Benoit
Current Opinion in Biomedical Engineering. 2021; : 100308
[Pubmed] | [DOI]
34 Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of natural products as promising systems for their bioactivity enhancement: The case of essential oils and flavonoids
Annita Katopodi,Anastasia Detsi
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021; 630: 127529
[Pubmed] | [DOI]
35 Supramolecular lipid nanoparticles as delivery carriers for non-invasive cancer theranostics
Syeda Zunaira Bukhari, Kornelius Zeth, Maryam Iftikhar, Mubashar Rehman, Muhammad Usman Munir, Waheed S. Khan, Ayesha Ihsan
Current Research in Pharmacology and Drug Discovery. 2021; 2: 100067
[Pubmed] | [DOI]
36 Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors
Shriya Reddy,Katyayani Tatiparti,Samaresh Sau,Arun K. Iyer
Drug Discovery Today. 2021;
[Pubmed] | [DOI]
37 Recent update of toxicity aspects of nanoparticulate systems for drug delivery
Soma Patnaik,Bapi Gorain,Santwana Padhi,Hira Choudhury,Gamal A. Gabr,Shadab Md,Dinesh Kumar Mishra,Prashant Kesharwani
European Journal of Pharmaceutics and Biopharmaceutics. 2021;
[Pubmed] | [DOI]
38 Nanotherapeutics approaches for targeting alpha synuclien protein in the management of Parkinson disease
Ajit Singh,Sandeep Kumar Maharana,Rahul Shukla,Prashant Kesharwani
Process Biochemistry. 2021;
[Pubmed] | [DOI]
39 Encapsulation of probiotics and nutraceuticals: Applications in functional food industry
Priscilla Magro Reque,Adriano Brandelli
Trends in Food Science & Technology. 2021; 114: 1
[Pubmed] | [DOI]
40 Coalition of Biological Agent (Melatonin) With Chemotherapeutic Agent (Amphotericin B) for Combating Visceral Leishmaniasis via Oral Administration of Modified Solid Lipid Nanoparticles
Shabi Parvez,Ganesh Yadagiri,Kanika Arora,Aaqib Javaid,Anurag Kumar Kushwaha,Om Prakash Singh,Shyam Sundar,Shyam Lal Mudavath
ACS Biomaterials Science & Engineering. 2021;
[Pubmed] | [DOI]
41 Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease
Rou Tang, Rui Li, He Li, Xiao-Lei Ma, Peng Du, Xiao-You Yu, Ling Ren, Lu-Lu Wang, Wen-Sheng Zheng
ACS Nano. 2021; 15(11): 17016
[Pubmed] | [DOI]
42 Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
Ummu Umaimah Mohd Nordin,Noraini Ahmad,Norazlinaliza Salim,Nor Saadah Mohd Yusof
RSC Advances. 2021; 11(46): 29080
[Pubmed] | [DOI]
43 Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line
Mohammad Sharifalhoseini,Ali Es-haghi,Gholamhassan Vaezi,Hooman Shajiee
IET Nanobiotechnology. 2021;
[Pubmed] | [DOI]
44 Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics
Mohammad Mahmoudian,Hadi Valizadeh,Raimar Löbenberg,Parvin Zakeri-Milani
Journal of Microencapsulation. 2021; : 1
[Pubmed] | [DOI]
45 Nano-Lipidic Formulation and Therapeutic Strategies for Alzheimer’s disease via Intranasal Route
Shourya Tripathi,Ujala Gupta,Rewati Raman Ujjwal,Awesh K. Yadav
Journal of Microencapsulation. 2021; : 1
[Pubmed] | [DOI]
46 Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment
Eman Abd-Elhakeem,Mohamed El-Nabarawi,Rehab Shamma
Drug Delivery. 2021; 28(1): 642
[Pubmed] | [DOI]
47 A Recent Update on Drug Delivery Systems for Pain Management
Apoorva Phadke,Purnima Amin
Journal of Pain & Palliative Care Pharmacotherapy. 2021; : 1
[Pubmed] | [DOI]
48 Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria
Ritika Chatterjee,Atish Roy Chowdhury,Debapriya Mukherjee,Dipshikha Chakravortty
Virulence. 2021; 12(1): 195
[Pubmed] | [DOI]
49 Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering
Mahsa Ahmadi,Mehdi Mehdikhani,Jaleh Varshosaz,Shadi Farsaei,Hadis Torabi
Journal of Biomaterials Applications. 2021; 35(8): 958
[Pubmed] | [DOI]
50 Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls
Morteza Heidarzadeh,Yasemin Gürsoy-Özdemir,Mehmet Kaya,Aysan Eslami Abriz,Amir Zarebkohan,Reza Rahbarghazi,Emel Sokullu
Cell & Bioscience. 2021; 11(1)
[Pubmed] | [DOI]
51 Preparation and evaluation of adapalene nanostructured lipid carriers for targeted drug delivery in acne
Saman Ahmad Nasrollahi,Faezeh Koohestani,Atefeh Naeimifar,Aniseh Samadi,Alireza Vatanara,Alireza Firooz
Dermatologic Therapy. 2021;
[Pubmed] | [DOI]
52 Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature
Kah Min Yap, Mahendran Sekar, Shivkanya Fuloria, Yuan Seng Wu, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Vetriselvan Subramaniyan, Chandrakant Kokare, Pei Teng Lum, M Yasmin Begum, Shankar Mani, Dhanalekshmi Unnikrishnan Meenakshi, Kathiresan V Sathasivam, Neeraj Kumar Fuloria
International Journal of Nanomedicine. 2021; Volume 16: 7891
[Pubmed] | [DOI]
53 Herbal Nanoformulations for Asthma Treatment
Jing Yang, Bo Song, Junzi Wu
Current Pharmaceutical Design. 2021; 27
[Pubmed] | [DOI]
54 Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review
Simon N. Mbugua,Lydia W. Njenga,Ruth A. Odhiambo,Shem O. Wandiga,Martin O. Onani
Current Topics in Medicinal Chemistry. 2021; 21(1): 28
[Pubmed] | [DOI]
55 Formulation and Evaluation of Valsartan Solid Lipid Nanoparticles
M. Chandana,M. Venkata Ramana,N. Rama Rao
Journal of Drug Delivery and Therapeutics. 2021; 11(2-S): 103
[Pubmed] | [DOI]
56 Protein-Based Nanohydrogels for Bioactive Delivery
Subhash Chander,Giriraj T. Kulkarni,Neerupma Dhiman,Harsha Kharkwal
Frontiers in Chemistry. 2021; 9
[Pubmed] | [DOI]
57 Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers
Ina F. de la Fuente,Shraddha S. Sawant,Mark Q. Tolentino,Patrick M. Corrigan,Jessica L. Rouge
Frontiers in Chemistry. 2021; 9
[Pubmed] | [DOI]
58 Polymers Blending as Release Modulating Tool in Drug Delivery
Parisa Ghasemiyeh, Soliman Mohammadi-Samani
Frontiers in Materials. 2021; 8
[Pubmed] | [DOI]
59 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?
Roseane Guimarães Ferreira,Luis Eduardo Mosquera Narvaez,Kaio Murilo Monteiro Espíndola,Amanda Caroline R. S. Rosario,Wenddy Graziela N. Lima,Marta Chagas Monteiro
Frontiers in Oncology. 2021; 11
[Pubmed] | [DOI]
60 Solid Lipid Nanoparticles as Carriers for the Synthetic Opioid LP2: Characterization and In Vitro Release
Angelo Spadaro, Lorella Pasquinucci, Miriam Lorenti, Ludovica Maria Santagati, Maria Grazia Sarpietro, Rita Turnaturi, Carmela Parenti, Lucia Montenegro
Applied Sciences. 2021; 11(21): 10250
[Pubmed] | [DOI]
61 Trends in Nanotechnology and Its Potentialities to Control Plant Pathogenic Fungi: A Review
Abdulaziz Bashir Kutawa,Khairulmazmi Ahmad,Asgar Ali,Mohd Zobir Hussein,Mohd Aswad Abdul Wahab,Abdullahi Adamu,Abubakar A. Ismaila,Mahesh Tiran Gunasena,Muhammad Ziaur Rahman,Md Imam Hossain
Biology. 2021; 10(9): 881
[Pubmed] | [DOI]
62 Advanced Nanoparticle-Based Drug Delivery Systems and Their Cellular Evaluation for Non-Small Cell Lung Cancer Treatment
Noratiqah Mohtar,Thaigarajan Parumasivam,Amirah Mohd Gazzali,Chu Shan Tan,Mei Lan Tan,Rozana Othman,Siti Sarah Fazalul Rahiman,Habibah A. Wahab
Cancers. 2021; 13(14): 3539
[Pubmed] | [DOI]
63 Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models
Kadie Edwards,Seydou Yao,Simone Pisano,Veronica Feltracco,Katja Brusehafer,Sumanta Samanta,Oommen P. Oommen,S. Andrea Gazze,Roberta Paravati,Holly Maddison,Chao Li,Deyarina Gonzalez,R. Steven Conlan,Lewis Francis
Cancers. 2021; 13(16): 4032
[Pubmed] | [DOI]
64 Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids?
Jian Sheng Loh, Li Kar Stella Tan, Wai Leng Lee, Long Chiau Ming, Chee Wun How, Jhi Biau Foo, Nurolaini Kifli, Bey Hing Goh, Yong Sze Ong
Cancers. 2021; 13(21): 5346
[Pubmed] | [DOI]
65 Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review
Dima Khater,Hamdi Nsairat,Fadwa Odeh,Mais Saleh,Areej Jaber,Walhan Alshaer,Abeer Al Bawab,Mohammad S. Mubarak
Cosmetics. 2021; 8(2): 39
[Pubmed] | [DOI]
66 Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment
John Jairo Aguilera-Correa,Jaime Esteban,María Vallet-Regí
Nanomaterials. 2021; 11(1): 137
[Pubmed] | [DOI]
67 Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy
Saffiya Habib,Moganavelli Singh
Nanomaterials. 2021; 11(3): 597
[Pubmed] | [DOI]
68 A Multifunctional Polymeric Micelle for Targeted Delivery of Paclitaxel by the Inhibition of the P-Glycoprotein Transporters
Sobia Razzaq, Aisha Rauf, Abida Raza, Sohail Akhtar, Tanveer A. Tabish, Mansur Abdullah Sandhu, Muhammad Zaman, Ibrahim M. Ibrahim, Gul Shahnaz, Abbas Rahdar, Ana M. Díez-Pascual
Nanomaterials. 2021; 11(11): 2858
[Pubmed] | [DOI]
69 The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update
Reem Abou Assi,Ibrahim M. Abdulbaqi,Chan Siok Yee
Pharmaceuticals. 2021; 14(3): 215
[Pubmed] | [DOI]
70 In Vitro Studies on Nasal Formulations of Nanostructured Lipid Carriers (NLC) and Solid Lipid Nanoparticles (SLN)
Cláudia Pina Costa,Sandra Barreiro,João Nuno Moreira,Renata Silva,Hugo Almeida,José Manuel Sousa Lobo,Ana Catarina Silva
Pharmaceuticals. 2021; 14(8): 711
[Pubmed] | [DOI]
71 Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies
Viliana Gugleva,Nadezhda Ivanova,Yoana Sotirova,Velichka Andonova
Pharmaceuticals. 2021; 14(9): 837
[Pubmed] | [DOI]
72 Nanostructured Lipid Carrier–Mediated Transdermal Delivery of Aceclofenac Hydrogel Present an Effective Therapeutic Approach for Inflammatory Diseases
Neeraj K. Garg,Nikunj Tandel,Sanjay Kumar Bhadada,Rajeev K. Tyagi
Frontiers in Pharmacology. 2021; 12
[Pubmed] | [DOI]
73 An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles
Luciana de Souza Guedes,Renata Miliani Martinez,Nádia A. Bou-Chacra,Maria Valéria Robles Velasco,Catarina Rosado,André Rolim Baby
Antioxidants. 2021; 10(7): 1034
[Pubmed] | [DOI]
74 Ezetimibe-Loaded Nanostructured Lipid Carrier Based Formulation Ameliorates Hyperlipidaemia in an Experimental Model of High Fat Diet
Yogeeta O. Agrawal,Umesh B. Mahajan,Vinit V. Agnihotri,Mayur S. Nilange,Hitendra S. Mahajan,Charu Sharma,Shreesh Ojha,Chandragouda R. Patil,Sameer N. Goyal
Molecules. 2021; 26(5): 1485
[Pubmed] | [DOI]
75 Lipidic Matrixes Containing Clove Essential Oil: Biological Activity, Microstructural and Textural Studies
John Rojas,Sergio Cabrera,Julie Benavides,Yasmín Lopera,Cristhian J. Yarce
Molecules. 2021; 26(9): 2425
[Pubmed] | [DOI]
76 Naringenin Nano-Delivery Systems and Their Therapeutic Applications
Mohammed Bhia,Mahzad Motallebi,Banafshe Abadi,Atefeh Zarepour,Miguel Pereira-Silva,Farinaz Saremnejad,Ana Cláudia Santos,Ali Zarrabi,Ana Melero,Seid Mahdi Jafari,Mehdi Shakibaei
Pharmaceutics. 2021; 13(2): 291
[Pubmed] | [DOI]
77 Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research
Monica Argenziano,Silvia Arpicco,Paola Brusa,Roberta Cavalli,Daniela Chirio,Franco Dosio,Marina Gallarate,Elena Peira,Barbara Stella,Elena Ugazio
Pharmaceutics. 2021; 13(10): 1538
[Pubmed] | [DOI]
78 Nose to Brain Delivery of Phenytoin Sodium Loaded Nano Lipid Carriers: Formulation, Drug Release, Permeation and In Vivo Pharmacokinetic Studies
Sreeja C. Nair,Kollencheri Puthenveettil Vinayan,Sabitha Mangalathillam
Pharmaceutics. 2021; 13(10): 1640
[Pubmed] | [DOI]
79 Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier
David Lee, Tamara Minko
Pharmaceutics. 2021; 13(12): 2049
[Pubmed] | [DOI]
80 Use of nanosystems to improve the anticancer effects of curcumin
Andrea M Araya-Sibaja,Norma J Salazar-López,Krissia Wilhelm Romero,José R Vega-Baudrit,J Abraham Domínguez-Avila,Carlos A Velázquez Contreras,Ramón E Robles-Zepeda,Mirtha Navarro-Hoyos,Gustavo A González-Aguilar
Beilstein Journal of Nanotechnology. 2021; 12: 1047
[Pubmed] | [DOI]
81 Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1
Eun Sil Kang,Hyo Juong Kim,Sung Gu Han,Han Geuk Seo
Food Science of Animal Resources. 2020; 40(1): 106
[Pubmed] | [DOI]
82 Nanocarriers as Magic Bullets in the Treatment of Leukemia
Mohammad Houshmand,Francesca Garello,Paola Circosta,Rachele Stefania,Silvio Aime,Giuseppe Saglio,Claudia Giachino
Nanomaterials. 2020; 10(2): 276
[Pubmed] | [DOI]
83 Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies
Maria Inês Teixeira,Maria Helena Amaral,Paulo C. Costa,Carla M. Lopes,Dimitrios A. Lamprou
Pharmaceutics. 2020; 12(6): 542
[Pubmed] | [DOI]
84 Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria
Sibusiso Alven,Blessing Atim Aderibigbe
Pharmaceutics. 2020; 12(8): 748
[Pubmed] | [DOI]
85 Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment
Reem Abou Assi,Ibrahim M. Abdulbaqi,Toh Seok Ming,Chan Siok Yee,Habibah A. Wahab,Shaik Mohammed Asif,Yusrida Darwis
Pharmaceutics. 2020; 12(11): 1052
[Pubmed] | [DOI]
86 Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid
Guendalina Zuccari,Sara Baldassari,Giorgia Ailuno,Federica Turrini,Silvana Alfei,Gabriele Caviglioli
Applied Sciences. 2020; 10(10): 3353
[Pubmed] | [DOI]
87 Nanolipoidal a-terpineol modulates quorum sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa
Sunil Kumar Bose,Pradip Nirbhavane,Mahak Batra,Sanjay Chhibber,Kusum Harjai
Nanomedicine. 2020; 15(18): 1743
[Pubmed] | [DOI]
88 Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance
Matthew Drayton,Jayachandran N. Kizhakkedathu,Suzana K. Straus
Molecules. 2020; 25(13): 3048
[Pubmed] | [DOI]
89 Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo
Rowshan Ara Islam,Hamed Al-Busaidi,Rahela Zaman,Syafiq Asnawi Zainal Abidin,Iekhsan Othman,Ezharul Hoque Chowdhury
Journal of Functional Biomaterials. 2020; 11(3): 63
[Pubmed] | [DOI]
90 Nano targeted Therapies Made of Lipids and Polymers have Promising Strategy for the Treatment of Lung Cancer
Marwa Labib Essa,Maged Abdeltawab El-Kemary,Eman Mohammed Ebrahem Saied,Stefano Leporatti,Nemany Abdelhamid Nemany Hanafy
Materials. 2020; 13(23): 5397
[Pubmed] | [DOI]
91 Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
Feng Zhao,Ping Wang,Yuanyuan Jiao,Xiaoxiao Zhang,Daquan Chen,Haiyu Xu
Frontiers in Pharmacology. 2020; 11
[Pubmed] | [DOI]
92 Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy
Geeta S. Bhagwat,Rajani B. Athawale,Rajeev P. Gude,Shadab Md,Nabil A. Alhakamy,Usama A. Fahmy,Prashant Kesharwani
Frontiers in Pharmacology. 2020; 11
[Pubmed] | [DOI]
93 Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review
Zeinab Nouri,Marziyeh Hajialyani,Zhila Izadi,Roodabeh Bahramsoltani,Mohammad Hosein Farzaei,Mohammad Abdollahi
Frontiers in Bioengineering and Biotechnology. 2020; 8
[Pubmed] | [DOI]
94 Nanoparticle-Mediated Drug Delivery for Treatment of Ischemic Heart Disease
Chengming Fan,Jyotsna Joshi,Fan Li,Bing Xu,Mahmood Khan,Jinfu Yang,Wuqiang Zhu
Frontiers in Bioengineering and Biotechnology. 2020; 8
[Pubmed] | [DOI]
95 Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy
Bijay Singh,Shicheng Yang,Apurva Krishna,Srinivas Sridhar
Frontiers in Chemistry. 2020; 8
[Pubmed] | [DOI]
96 Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications
Kuldeep Rajpoot
Current Cancer Drug Targets. 2020; 20(4): 271
[Pubmed] | [DOI]
97 Orally Administered Nanotherapeutics For Parkinson’s Disease: An Old Delivery System Yet More Acceptable
Nidhi Aggarwal,Zufika Qamar,Saleha Rehman,Sanjula Baboota,Javed Ali
Current Pharmaceutical Design. 2020; 26(19): 2280
[Pubmed] | [DOI]
98 Development and characterisation of a novel krill oil nanostructured lipid carrier based on 1,3-glycerol distearate
Yunwei Lin,Wenting Yin,Guoqin Liu
International Journal of Food Science & Technology. 2020;
[Pubmed] | [DOI]
99 Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects
Zhonghua Dong,Sajid Iqbal,Zhongxi Zhao
AAPS PharmSciTech. 2020; 21(2)
[Pubmed] | [DOI]

Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages

Parisa Ghasemiyeh,Soliman Mohammadi-Samani
Drug Design, Development and Therapy. 2020; Volume 14: 3271
[Pubmed] | [DOI]

Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer

Elaheh Entezar-Almahdi,Soliman Mohammadi-Samani,Lobat Tayebi,Fatemeh Farjadian
International Journal of Nanomedicine. 2020; Volume 15: 5445
[Pubmed] | [DOI]

Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds

Xin Nie,Zhejie Chen,Lan Pang,Lin Wang,Huajuan Jiang,Yi Chen,Zhen Zhang,Chaomei Fu,Bo Ren,Jinming Zhang
International Journal of Nanomedicine. 2020; Volume 15: 10215
[Pubmed] | [DOI]
103 A new agent for the treatment of lung cancer: B13 loaded solid lipid nanoparticles
Emre Çömlekçi,Hatice Mehtap Kutlu,Canan Vejselova Sezer
Advances in Natural Sciences: Nanoscience and Nanotechnology. 2020; 11(4): 045014
[Pubmed] | [DOI]
104 NIR-II Dual-Modal Optical Coherence Tomography and Photoacoustic Imaging-Guided Dose-Control Cancer Chemotherapy
Yubin Liu,Mengze Xu,Yunlu Dai,Qi Zhao,Lipeng Zhu,Xiaowen Guan,Gang Li,Sihua Yang,Zhen Yuan
ACS Applied Polymer Materials. 2020;
[Pubmed] | [DOI]
105 Novel biomimetic nanostructured lipid carriers for cancer therapy: preparation, characterization, and in vitro/in vivo evaluation
Jianwen Zhou,Biru Guo,Wenquan Zhu,Xiaoyu Sui,Xiaoxing Ma,Jiayi Qian,Lixin Cao,Cuiyan Han
Pharmaceutical Development and Technology. 2020; : 1
[Pubmed] | [DOI]
106 Management of epileptic disorders using nanotechnology-based strategies for nose-to-brain drug delivery
Mihika Shringarpure,Sankalp Gharat,Munira Momin,Abdelwahab Omri
Expert Opinion on Drug Delivery. 2020;
[Pubmed] | [DOI]
107 The advantages of nanomedicine in the treatment of visceral leishmaniasis: between sound arguments and wishful thinking
Kevin Matha,Brice Calvignac,Jean-Pierre Gangneux,Jean-Pierre Benoit
Expert Opinion on Drug Delivery. 2020; : 1
[Pubmed] | [DOI]
108 Challenges identifying efficacious miRNA therapeutics for cancer
Meirav Segal,Frank J. Slack
Expert Opinion on Drug Discovery. 2020; : 1
[Pubmed] | [DOI]
109 Preparation and evaluation of inhalable dry powder containing glucosamine-conjugated gefitinib SLNs for lung cancer therapy
Nazafarin Satari,Somayeh Taymouri,Jaleh Varshosaz,Mahboubeh Rostami,Mina Mirian
Drug Development and Industrial Pharmacy. 2020; : 1
[Pubmed] | [DOI]
110 Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats
Saud Bawazeer,Dalia Farag A. El-Telbany,Majid Mohammad Al-Sawahli,Gamal Zayed,Ahmed Abdallah A. Keed,Abdelaziz E. Abdelaziz,Doaa H. Abdel-Naby
Drug Delivery. 2020; 27(1): 1218
[Pubmed] | [DOI]
111 Emerging vaccine delivery systems for COVID-19
Nigel Theobald
Drug Discovery Today. 2020;
[Pubmed] | [DOI]
112 Low temperature, easy scaling upmethod for development of smart nanostructure hybrid lipid capsulesfor drug delivery application
Sunil Kumar Yadava,Suparna Mercy Basu,Meenakshi Chauhan,Kshipra Sharma,Apran Pradhan,Remya V.,Jyotsnendu Giri
Colloids and Surfaces B: Biointerfaces. 2020; : 110927
[Pubmed] | [DOI]
113 Enhanced In Vitro Antimicrobial Activity of Polymyxin B–Coated Nanostructured Lipid Carrier Containing Dexamethasone Acetate
Emmily Dantas Rocha,Marcia Regina Spuri Ferreira,Edson dos Santos Neto,Eduardo José Barbosa,Raimar Löbenberg,Felipe Rebello Lourenço,Nadia Bou-Chacra
Journal of Pharmaceutical Innovation. 2020;
[Pubmed] | [DOI]
114 Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases
Sevda Senel,Selin Yüksel
Drug Delivery and Translational Research. 2020;
[Pubmed] | [DOI]
115 Nanomedicine progress in thrombolytic therapy
Alina Zenych,Louise Fournier,Cédric Chauvierre
Biomaterials. 2020; 258: 120297
[Pubmed] | [DOI]
116 Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator
Shady M. Abd El-Halim,Ghada A. Abdelbary,Maha M. Amin,Mohamed Y. Zakaria,Hesham A. Shamsel-Din,Ahmed B. Ibrahim
DARU Journal of Pharmaceutical Sciences. 2020;
[Pubmed] | [DOI]
117 Nanoparticles for drug delivery in Parkinson’s disease
Jonathan Baskin,June Evelyn Jeon,Simon J. G. Lewis
Journal of Neurology. 2020;
[Pubmed] | [DOI]
118 Green Algae as a Drug Delivery System for the Controlled Release of Antibiotics
Inga S. Shchelik,Simon Sieber,Karl Gademann
Chemistry – A European Journal. 2020;
[Pubmed] | [DOI]
119 Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications
Fatemeh Sadat Hashemi,Farin Farzadnia,Abdoreza Aghajani,Farnaz Ahmadzadeh NobariAzar,Akram Pezeshki
Food Science & Nutrition. 2020;
[Pubmed] | [DOI]
120 Therapeutic benefits of rutin and its nanoformulations
Ramin Negahdari,Sepideh Bohlouli,Simin Sharifi,Solmaz Maleki Dizaj,Yalda Rahbar Saadat,Khadijeh Khezri,Samira Jafari,Elham Ahmadian,Negar G. Jahandizi,Safa Raeesi
Phytotherapy Research. 2020;
[Pubmed] | [DOI]
121 Advances in edible nanoemulsions: Digestion, bioavailability, and potential toxicity
David Julian McClements
Progress in Lipid Research. 2020; : 101081
[Pubmed] | [DOI]
122 Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
João Basso,Maria Mendes,Jessica Silva,José Sereno,Tânia Cova,Rui Oliveira,Ana Fortuna,Miguel Castelo-Branco,Amílcar Falcão,João Sousa,Alberto Pais,Carla Vitorino
European Journal of Pharmaceutics and Biopharmaceutics. 2020;
[Pubmed] | [DOI]
123 Zein coated calcium carbonate nanoparticles for the targeted controlled release of model antibiotic and nutrient across the intestine
Meenakshi Gautam,Deenan Santhiya,Namit Dey
Materials Today Communications. 2020; 25: 101394
[Pubmed] | [DOI]
124 Nanomaterials as potential transporters of HDAC inhibitors
Cristabelle De Souza,Aaron Raymond Lindstrom,Zhao Ma,Biswa Prasun Chatterji
Medicine in Drug Discovery. 2020; : 100040
[Pubmed] | [DOI]
125 A Short review on the antimicrobial micro- and nanoparticles loaded with Melaleuca alternifolia essential oil
Mariana Alves Battisti,Thiago Caon,Angela Machado de Campos
Journal of Drug Delivery Science and Technology. 2020; : 102283
[Pubmed] | [DOI]
126 Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinsonæs disease
Edilson Ribeiro de Oliveira Junior,Eleonora Truzzi,Luca Ferraro,Marco Fogagnolo,Barbara Pavan,Sarah Beggiato,Cecilia Rustichelli,Eleonora Maretti,Eliana Martins Lima,Eliana Leo,Alessandro Dalpiaz
Journal of Controlled Release. 2020;
[Pubmed] | [DOI]
127 Squalene integrated NLC based gel of tamoxifen citrate for efficient treatment of psoriasis: A preclinical investigation
Amit Sharma,Deepak Kumar Upadhyay,Ganti Subrahmanya Sarma,Navjot Kaur,Ghanshyam Das Gupta,Raj Kumar Narang,Vineet Kumar Rai
Journal of Drug Delivery Science and Technology. 2020; : 101568
[Pubmed] | [DOI]
128 A comprehensive review of nano drug delivery system in the treatment of CNS disorders
K.M. Asha Spandana,Mahendran Bhaskaran,V.V.S.N.Reddy Karri,Jawahar Natarajan
Journal of Drug Delivery Science and Technology. 2020; : 101628
[Pubmed] | [DOI]
129 Drug delivery systems integrated with conventional and advanced treatment approaches toward cellulite reduction
Sara A. Abosabaa,Mona G. Arafa,Aliaa Nabil ElMeshad
Journal of Drug Delivery Science and Technology. 2020; : 102084
[Pubmed] | [DOI]
130 Development of respirable rifampicin loaded bovine serum albumin formulation for the treatment of pulmonary tuberculosis
Monica Joshi,Bala Prabhakar
Journal of Drug Delivery Science and Technology. 2020; : 102197
[Pubmed] | [DOI]
131 Novel nanotechnology approaches for diagnosis and therapy of breast, ovarian and cervical cancer in female: A review
Ameeduzzafar Zafar,Nabil K. Alruwaili,Syed Sarim Imam,Khalid Saad Alharbi,Muhammad Afzal,Nasser Hadal Alotaibi,Mohd Yasir,Mohammed Elmowafy,Sultan Alshehri
Journal of Drug Delivery Science and Technology. 2020; : 102198
[Pubmed] | [DOI]
132 Development of lipid nanoparticles containing the xanthone LEM2 for topical treatment of melanoma
Rafaela Malta,Joana B. Loureiro,Paulo Costa,Emília Sousa,Madalena Pinto,Lucília Saraiva,M. Helena Amaral
Journal of Drug Delivery Science and Technology. 2020; : 102226
[Pubmed] | [DOI]
133 Engineering approaches for drug delivery systems production and characterization
A.A. Barba,A. Dalmoro,S. Bochicchio,V. De Simone,D. Caccavo,M. Iannone,G. Lamberti
International Journal of Pharmaceutics. 2020; : 119267
[Pubmed] | [DOI]
134 The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems
Bruno Fonseca-Santos,Marlus Chorilli
International Journal of Pharmaceutics. 2020; 589: 119832
[Pubmed] | [DOI]
135 Design of nalidixic acid-vanadium complex loaded into chitosan hybrid nanoparticles as smart strategy to inhibit bacterial growth and quorum sensing
Bárbara Bueloni,Daniele Sanna,Eugenio Garribba,Guillermo R. Castro,Ignacio E. León,Germán A. Islan
International Journal of Biological Macromolecules. 2020; 161: 1568
[Pubmed] | [DOI]
136 Brain targeting of Baicalin and Salvianolic acid B combination by OX26 functionalized nanostructured lipid carriers
Yumei Wu,Xunan Song,Dereje Kebebe,Xinyue Li,Zhifeng Xue,Jiawei Li,Shouying Du,Jiaxin Pi,Zhidong Liu
International Journal of Pharmaceutics. 2019; : 118754
[Pubmed] | [DOI]
137 Engineered nano scale formulation strategies to augment efficiency of nutraceuticals
Asad Ali,Usama Ahmad,Juber Akhtar,Juber Badruddeen,Mohd Muazzam Khan
Journal of Functional Foods. 2019; 62: 103554
[Pubmed] | [DOI]
138 Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy
João A. Oshiro-Júnior,Mariana Rillo Sato,Fernanda Isadora Boni,Karen Loraine Macena Santos,Kleber Thiago de Oliveira,Laura Marise de Freitas,Carla Raquel Fontana,Dean Nicholas,Anthony McHale,John F. Callan,Marlus Chorilli
Materials Science and Engineering: C. 2019; : 110462
[Pubmed] | [DOI]
139 Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery
Nuzhat Zahin,Raihanatul Anwar,Devesh Tewari,Md. Tanvir Kabir,Amin Sajid,Bijo Mathew,Md. Sahab Uddin,Lotfi Aleya,Mohamed M. Abdel-Daim
Environmental Science and Pollution Research. 2019;
[Pubmed] | [DOI]
140 Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review
Eva C. Arrúa,Katia P. Seremeta,Giselle R. Bedogni,Nora B. Okulik,Claudio J. Salomon
Acta Tropica. 2019; 198: 105080
[Pubmed] | [DOI]
141 Nanoemulsions improve the efficacy of turmeric in palmitate- and high fat diet-induced cellular and animal models
Eun Ji Lee,Jung Seok Hwang,Eun Sil Kang,Su Bi Lee,Jinwoo Hur,Won Jin Lee,Mi-Jung Choi,Jun Tae Kim,Han Geuk Seo
Biomedicine & Pharmacotherapy. 2019; 110: 181
[Pubmed] | [DOI]
142 Colombian propolis as starting material for the preparation of nanostructured lipid carriers
Yuly X. Correa González,Alba L. Valenzuela Correa,Ángel M. Ardila Vargas,Maritza A. Rojas Cardozo,Claudia E. Mora Huertas
Revista Brasileira de Farmacognosia. 2019;
[Pubmed] | [DOI]
143 Cytotoxicity screening of emulsifiers for pulmonary application of lipid nanoparticles
Verena Steiner,Kristin Öhlinger,Carolina Corzo,Sharareh Salar-Behzadi,Eleonore Fröhlich
European Journal of Pharmaceutical Sciences. 2019; 136: 104968
[Pubmed] | [DOI]
144 Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting
Parisa Ghasemiyeh,Amir Azadi,Saeid Daneshamouz,Reza Heidari,Negar Azarpira,Soliman Mohammadi-Samani
Pharmaceutical Development and Technology. 2019; : 1
[Pubmed] | [DOI]
145 Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design
Gifty M. Jojo,Gowthamarajan Kuppusamy,Anindita De,V. V. S. Narayan Reddy Karri
Drug Development and Industrial Pharmacy. 2019; : 1
[Pubmed] | [DOI]
146 Recent advances in metallopolymer-based drug delivery systems
Gulzhian I. Dzhardimalieva,Lev N. Rabinskiy,Kamila A. Kydralieva,Igor E. Uflyand
RSC Advances. 2019; 9(63): 37009
[Pubmed] | [DOI]
147 Analyzing Nanotheraputics-Based Approaches for the Management of Psychotic Disorders
Malay Annu,Saleha Rehman,Shadab Md,Sanjula Baboota,Javed Ali
Journal of Pharmaceutical Sciences. 2019;
[Pubmed] | [DOI]
148 Comparative effects of nanoemulsions loaded with duck oil and lard oil on palmitate-induced lipotoxicity
Eun Sil Kang,Jinwoo Hur,Yoenji Jo,Hyo Juong Kim,Sung Gu Han,Han Geuk Seo
Journal of Food Biochemistry. 2019;
[Pubmed] | [DOI]
149 Nutraceuticals’ Novel Formulations: The Good, the Bad, the Unknown and Patents Involved
Nada A. Helal,Heba A. Eassa,Ahmed M. Amer,Mohamed A. Eltokhy,Ivan Edafiogho,Mohamed I. Nounou
Recent Patents on Drug Delivery & Formulation. 2019; 13(2): 105
[Pubmed] | [DOI]
150 Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art
Alfonso Di Costanzo,Ruggero Angelico
Molecules. 2019; 24(11): 2155
[Pubmed] | [DOI]
151 Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
Claudio J. Ketabat,Claudio J. Pundir,Claudio J. Mohabatpour,Claudio J. Lobanova,Claudio J. Koutsopoulos,Claudio J. Hadjiiski,Claudio J. Chen,Claudio J. Papagerakis,Claudio J. Papagerakis
Pharmaceutics. 2019; 11(7): 302
[Pubmed] | [DOI]
152 Anti-Angiogenic Effect of Orally Available Pemetrexed for Metronomic Chemotherapy
V. V. S. Narayan Reddy Maharjan,V. V. S. Narayan Reddy Pangeni,V. V. S. Narayan Reddy Jha,V. V. S. Narayan Reddy Choi,V. V. S. Narayan Reddy Chang,V. V. S. Narayan Reddy Choi,V. V. S. Narayan Reddy Park,V. V. S. Narayan Reddy Byun
Pharmaceutics. 2019; 11(7): 332
[Pubmed] | [DOI]
153 Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications
Anna Angela Barba,Sabrina Bochicchio,Annalisa Dalmoro,Gaetano Lamberti
Pharmaceutics. 2019; 11(8): 360
[Pubmed] | [DOI]
154 An Overview of the Role of Nanoparticles in Handling the Breast Cancer
Roghayeh Abbasalipourkabir,Nasrin Ziamajidi
Avicenna Journal of Medical Biochemistry. 2019; 7(1): 1
[Pubmed] | [DOI]
155 Surface modified kokum butter lipid nanoparticles for the brain targeted delivery of nevirapine
Sunita Lahkar,Malay Kumar Das
Journal of Microencapsulation. 2018; 35(7-8): 680
[Pubmed] | [DOI]
156 Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release
Aldemar Gordillo-Galeano,Claudia Elizabeth Mora-Huertas
European Journal of Pharmaceutics and Biopharmaceutics. 2018; 133: 285
[Pubmed] | [DOI]
157 Improved delivery of voriconazole to Aspergillus fumigatus through solid lipid nanoparticles as an effective carrier
Hamid Reza Kelidari,Roghayeh Babaei,Mojtaba Nabili,Tahereh Shokohi,Majid Saeedi,Sara Gholami,Maryam Moazeni,Ali Nokhodchi
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2018; 558: 338
[Pubmed] | [DOI]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
  1. Introduction
   2. Types of Lipi...
   3. Methods of Li...
   4. Lipid Nanopar...
   5. Commercially ...
  6. Conclusion
   Article Figures
   Article Tables

 Article Access Statistics
    PDF Downloaded2420    
    Comments [Add]    
    Cited by others 157    

Recommend this journal